This is already recurring problem with games exe produced by pyinstaller with eg pygame games, i’m not surprised at all it will affect Panda3D.
To get rid of false positive you can self sign the exe, but to keep your players trust for distributing the game in eg. a game jam it will cost you a real certificate.
An alternative could be (experimental) to run Panda3D in the internet browser but then shaders must be close to GLES 3.0