Will Panda work for me?

What do you mean on “database”? Panda can load models on the fly, including loading models in parallel thread, as far as I know.

About Blender exporter - do you try YABEE? If it not works for you, then you can say what you want and we can try to improve exporter, or you can modyfi it yourself.

Python and C++ is similar in context of access to the engine, but python contain bunch of helpers, which simplify and accelerates your work.

You can extend python by C++ libraries due to performance or security approach